A Meta-analysis in multi-center random controlled clinical trials

To study the center effect discrepancy in the multi-center clinical trials. Two groups of data collected from the multi-center clinical trials were used. Data were processed by covariance analysis and Meta-analysis. In the covariance analysis, the discrepancy of the center effect values indicated st...

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Bibliographic Details
Published inZhōnghuá liúxíngbìng zázhì Vol. 26; no. 4; p. 290
Main Authors Ou, Ai-hua, Lao, Ying-rong, Li, Xiao-qing, Huang, Yan, He, Yi-ting, Huang, Pei-xin
Format Journal Article
LanguageChinese
Published China 01.04.2005
Subjects
Data Collection
Humans
Multicenter Studies as Topic - methods
Randomized Controlled Trials as Topic - methods
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Summary:To study the center effect discrepancy in the multi-center clinical trials. Two groups of data collected from the multi-center clinical trials were used. Data were processed by covariance analysis and Meta-analysis. In the covariance analysis, the discrepancy of the center effect values indicated statistical significance. Through Meta-analysis on fixed effect model, the discrepancy in one heterogeneity test showed no statistical significance (P > 0.05) while the inter-group discrepancy of the merged effect values drawn from analysis based on fixed effect model having statistical significance (P < 0.05). In the random effect model, the discrepancy in one heterogeneity test showed statistical significance (P < 0.05) while the inter-group discrepancy of the merged effect values drawn from analysis based on random effect model having no statistical significance (P > 0.05). Studies on multi-center random controlled clinical trials, when statistical significance was found in the interaction discrepancy between the
ISSN:0254-6450