Experimental retinal vein occlusion induced by photodynamic approach

To develop a new photochemical method of experimental retinal vein occlusion and investigate the morphologic and histologic changes in the retina. After intravenous injection of rose Bengal, the vessels next to the disc of miniature pigs in the experiment group (n = 15) were exposed to an endo-illum...

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Published inChung-hua yen k'o tsa chih Vol. 39; no. 4; p. 220
Main Authors Zhang, Xiao-li, Hu, Yun-tao, Ma, Zhi-zhong, Wang, Chang-guan, Han, Su-yi, Yang, Bing-jian, Huang, Li-jie
Format Journal Article
LanguageChinese
Published China 01.04.2003
Subjects
Animals
Disease Models, Animal
Female
Male
Photochemotherapy - adverse effects
Retinal Vein Occlusion - etiology
Retinal Vein Occlusion - pathology
Rose Bengal - adverse effects
Swine
Swine, Miniature
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Summary:To develop a new photochemical method of experimental retinal vein occlusion and investigate the morphologic and histologic changes in the retina. After intravenous injection of rose Bengal, the vessels next to the disc of miniature pigs in the experiment group (n = 15) were exposed to an endo-illuminator for 15 minutes. As a control group, the vessels next to the disc of each pig were exposed to the endo-illuminator without rose Bengal injection. After complete vascular occlusion, the eyes were observed at following times: one hour, and 1, 3, 7, 14, 21, and 28 days. After the 28th day, the eyes were enucleated and prepared for light and electron microscope examination. Histopathologic features were consistent with changes of retinal vein occlusion and formation of retinal vein thrombi was reliable. Photodynamic method combined with endo-illuminator was a simple, reliable and definitive experimental technique to produce retinal vein occlusion.
ISSN:0412-4081