Quantitative analysis of regional cerebral blood flow in elderly with white matter lesions

To observe whether the severity of white matter lesions (WML) is related to ischemia in elderly. WML were divided into 2 categories (centrum semiovale and periventricular regions) and four grades (grade 0, grade 1, grade 2 and grade 3) according to the severity of WML showing on the FLAIR sequence o...

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Published inZhong hua yi xue za zhi Vol. 89; no. 17; p. 1175
Main Authors Fu, Jian-hui, Yuan, Jing, Li, Sheng, Guo, Qi-hao, Hong, Zhen, Dong, Qiang, Lü, Chuan-zhen, Zhao, Qian-hua
Format Journal Article
LanguageChinese
Published China 05.05.2009
Subjects
Aged
Brain - blood supply
Brain - pathology
Cerebrovascular Circulation
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Regional Blood Flow
Tomography, X-Ray Computed - methods
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Summary:To observe whether the severity of white matter lesions (WML) is related to ischemia in elderly. WML were divided into 2 categories (centrum semiovale and periventricular regions) and four grades (grade 0, grade 1, grade 2 and grade 3) according to the severity of WML showing on the FLAIR sequence of MRI using modified Fazekas scale. The values of regional cerebral blood flow (rCBF) within WML and other brain regions were measured using Xenon contrast CT. Mean rCBF (ml x 100 g(-1) x min(-1)) within lesions around periventricular areas, in right and left centrum semiovale were 20.8 +/- 2.8, 22.3 +/- 1.9 and 22.2 +/- 2.1 in grade 0; 20.3 +/- 2.5, 21.3 +/- 1.0 and 21.0 +/- 1.8 in grade1; 16.3 +/- 2.0, 15.6 +/- 1.7 and 15.9 +/- 0.9 in grade 2; 14.1 +/- 2.6, 14.5 +/- 2.2 and 14.2 +/- 1.9 in grade 3 respectively. The severity of WML is associated significantly with reduction of rCBF within lesions both in centrum semiovale and periventricular regions (all P < 0.05). There was no significant difference in rCBF value
ISSN:0376-2491
DOI:10.3760/cma.j.issn.0376-2491.2009.17.007