Experimental study on replicating knee osteoarthritis by modified Hulth's modeling method

To explore the method of replicating experimental animal model of knee osteoarthritis. Knee osteoarthritis was replicated by modified Hulth's modeling method. X-ray photographic and transmission electron microscopic examination, test of the joint synovial fluid of the modeled joint were perform...

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Published inZhongguo Zhong xi yi jie he za zhi Vol. 25; no. 12; p. 1104
Main Authors Liu, Xian-xiang, Li, Xi-hai, Zhou, Jiang-tao
Format Journal Article
LanguageChinese
Published China 01.12.2005
Subjects
Animals
Disease Models, Animal
Female
Male
Osteoarthritis, Knee
Rabbits
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Summary:To explore the method of replicating experimental animal model of knee osteoarthritis. Knee osteoarthritis was replicated by modified Hulth's modeling method. X-ray photographic and transmission electron microscopic examination, test of the joint synovial fluid of the modeled joint were performed, and serum contents of malondialdehyde (MDA) and nitric oxide (NO) in blood were measured. (1) In the normal control group, the articular surface is smooth and glossy, with intact cells and cellular membrane. In the model group, the medial space of the knee joint became obvious narrowed with rough and deformed articular surface and osteophytes, as well as the atrophic chondrocytes with pyknotic cell nucleus and broken cellular membrane. (2) Eight weeks and 16 weeks after modeling, in the model group, the contents of interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and matrix metalloproteinase-3 (MMP-3) in synovial fluid and the levels of serum MDA and NO were obviously raised, and t
ISSN:1003-5370