Characteristic of inflammatory infiltrate of gastric mucosa in patients with grade II-III gastric dysplasia and of stomach cancer

The study included 85 inpatients and outpatients in whom composition of inflammatory infiltrate from gastric mucosa (GM) was determined at the Oncological Research Institute, Tomsk Research Centre of the Siberian Division, Russian Academy of Medical Sciences. The patients were allocated to 4 groups...

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Published inKlinicheskaia meditsina Vol. 86; no. 11; p. 48
Main Authors Evtushenko, V A, Vusik, M V, Karakeshisheva, M B, Pleshko, R I, Ermolaeva, L A
Format Journal Article
LanguageRussian
Published Russia (Federation) 2008
Subjects
Adenocarcinoma - pathology
Adenocarcinoma, Mucinous - metabolism
Adenocarcinoma, Mucinous - pathology
Adult
Eosinophils - metabolism
Female
Gastric Mucosa - metabolism
Gastric Mucosa - pathology
Humans
Inflammation - parasitology
Lymphocytes - metabolism
Male
Middle Aged
Neoplasm Staging
Neutrophils - metabolism
Stomach Neoplasms - metabolism
Stomach Neoplasms - pathology
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Summary:The study included 85 inpatients and outpatients in whom composition of inflammatory infiltrate from gastric mucosa (GM) was determined at the Oncological Research Institute, Tomsk Research Centre of the Siberian Division, Russian Academy of Medical Sciences. The patients were allocated to 4 groups depending on nosological form of the disease. Group 1 comprised 21 patients with grade II-III GM epithelial dysplasia, group 2 - 24 patients having stomach cancer (histologically confirmed adenocarcinoma), group 3 - 19 patients with stage II-III mucinous gastric carcinoma, group 4 - 20 allegedly healthy subjects without signs of gastrointestinal pathology. It was shown that dysplastic processes in GM are associated with an increase of neutrophil, eosinophil, macrophage, and mast cell count along with a drop in the number of lymphocytes and plasmocytes. Stroma of invasive stomach cancer underwent intense inflammatory infiltration accompanied by a rise in the number of lymphocytes, plasmocytes, and neutrophils. Mucinous gastric carcinoma was characterized by an increase of the number of neutrophils and macrophages. Patients having adenocarcinoma of the stomach showed enhanced plasmocytic infiltration by plasmocytes with a low number of eosinophils and mast cells. It is concluded that characteristics of inflammatory GM infiltrate may be useful for the objective assessment of stomach cancer risk in patients with GM dysplasia, formation of a high oncological risk group, adequate dynamic monitoring and treatment of these patients.
ISSN:0023-2149