Effect of acupoint application therapy on expression of IL-4 and IFN-gamma in lung tissue of asthma rats

To observe the effect of acupoint application of Chinese herbal medicines on pathological changes of pulmonary tissue in asthma rats so as to explore its underlying mechanism. A total of 33 Wistar rats were randomized into normal control (n=6), model (n=9), dexamethasone (DX, n=9) and acupoint-appli...

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Published inZhēncì yánjiū Vol. 32; no. 3; p. 174
Main Authors Yao, Hong, Tong, Juan, Wang, Zheng, Zhang, Zi-qian, Chen, Jian-xiong
Format Journal Article
LanguageChinese
Published China 2007
Subjects
Acupuncture Points
Acupuncture Therapy
Animals
Asthma - immunology
Asthma - pathology
Asthma - therapy
Interferon-gamma - analysis
Interleukin-4 - analysis
Lung - immunology
Lung - pathology
Male
Rats
Rats, Wistar
Th1 Cells - immunology
Th2 Cells - immunology
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Summary:To observe the effect of acupoint application of Chinese herbal medicines on pathological changes of pulmonary tissue in asthma rats so as to explore its underlying mechanism. A total of 33 Wistar rats were randomized into normal control (n=6), model (n=9), dexamethasone (DX, n=9) and acupoint-application (A-A, n=9) groups. Asthma model was established by intraperitoneal injection of 10% ovalbumin(OVA, 1 mL)and forced inhalation of atomized 2% OVA (25 mL) for 40 min, once daily for 2 weeks. "Dazhui" (GV 14). "Pishu" (BL 20), "Feishu" (BL 13) and "Shenshu" (BL 23) were selected for external application of Chinese medicinal herbs (pricklyash peel, white mustard seeds, asarum herb, etc.) for rats of A-A group, and that of control drugs (ang-kak, black rice, ginger juice, etc) for rats of DX group. Infiltration degrees of eosinophils (Eos), lymphocytes (L) and macrophages (MO) in the pulmonary tissue were observed under microscope. IL-4 and IFN-gamma expression was displayed by using immunohistochemical method. I
ISSN:1000-0607