Application of synthetic analogue of somatostatin--octrestatin in the treatment of gastroduodenal erosions and acute ulcers complicated by hemorrhage

• Published in: Klinična hìrurgìâ (Kiïv) no. 1; p. 11
• Main Authors: Fomin, P D, Sydorenko, V M, Lissov, O I, Bobkov, O V
• Format: Journal Article
• Language: Ukrainian
• Published: Ukraine 01.01.2005
• Subjects: Acute Disease; Gastroenteritis - drug therapy; Gastroenteritis - epidemiology; Gastroenteritis - etiology; Gastrointestinal Agents - administration & dosage; Gastrointestinal Agents - therapeutic use; Humans; Octreotide - administration & dosage; Octreotide - therapeutic use; Peptic Ulcer - drug therapy; Peptic Ulcer - epidemiology; Peptic Ulcer - etiology; Peptic Ulcer Hemorrhage - drug therapy; Peptic Ulcer Hemorrhage - epidemiology; Peptic Ulcer Hemorrhage - etiology; Retrospective Studies; Treatment Outcome; Ukraine - epidemiology; Ukraine
• ISSN: 0023-2130

Retrospective analysis of diagnostic and curative processes in Kyiv's city centre of delivering the aid in gastrointestinal hemorrhage for 1131 patients in 1999--2003 yrs period was done. The classification of gastroduodenal erosions and an acute ulcers, complicated by hemorrhage, oriented on etiological factor involved, was proposed. Depending on etiological feature present, there were determined characteristic signs of mucosal affections, their localization and the hemorrhage severity. There was proved the expediency of introduction of the treatment results control, based on investigation of dehydrogenases activity, the intracellular glycogen content and the state of the lipids peroxidal oxidation. Clinical efficacy of synthetic analogue of somatostatin Octrestatin was studied in the treatment of gastroduodenal erosions and an acute ulcers in 26 patients. Application of Octrestatin have promoted the lipids metabolism normalization and acceleration of the mucosal ulcers healing by 2-3 days.