The effect of colcichine and iodine-lithium-alpha-dextrin on the phagocytosis of granulocytes and monocytes in patients with familial Mediterranean fever

Disturbances in the regulation of phagocytic activity of neutrophils and monocytes (PANM) in whole peripheral blood of patients with familial Mediterranean Fever (FMF), which had not received treatment with colchicines, were determined by quantitative flow cytofluorimetry. The effect of iodine-lithi...

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Published inĖksperimentalʹnaâ i kliničeskaâ farmacologiâ Vol. 68; no. 5; p. 36
Main Authors Akopian, V P, Avetisian, S A, Davtian, T K
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.09.2005
Subjects
Adolescent
Adult
Colchicine - pharmacology
Dextrins
Drug Carriers
Familial Mediterranean Fever - immunology
Female
Granulocytes - drug effects
Granulocytes - immunology
Humans
Iodine - therapeutic use
Lithium - therapeutic use
Male
Monocytes - drug effects
Monocytes - immunology
Phagocytosis - drug effects
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Summary:Disturbances in the regulation of phagocytic activity of neutrophils and monocytes (PANM) in whole peripheral blood of patients with familial Mediterranean Fever (FMF), which had not received treatment with colchicines, were determined by quantitative flow cytofluorimetry. The effect of iodine-lithium-alpha-dextrin (armenicum) and colchicine on the PANM in the blood of FMF patients was studied in vitro. The intensity of phagocytosis in populations of neutrophils and monocytes in FMF patients (n = 6) during the remission period is higher than that during the FMF attack (n = 6) and higher than in healthy donors (n = 9). The PANM in patients during the FMF attack is higher compared to that in healthy donors. Iodine-lithium-alpha-dextrin (armenicum) and colchicine inhibited the phagocytosis of effector cells in FMF patients in a dose-dependent and time-dependent manner. It was shown that the suppressive effect of the drugs increased with decreasing bacteria/effector cells ratio.
ISSN:0869-2092