Properties and application of oligodeoxynucleotides containing the naphthyridine:imidazopyridopyrimidine base pairs with the ability to form four hydrogen bonds

As our continuing study to develop base pairing motifs which stabilize and regulate DNA structure, we designed novel 1,8-naphthyridine C-nucleosides possessing Na-O(N) and Na-N(O) bases. These C-nucleosides formed two sets of naphthyridine:imidazopyridopyrimidine base pairing motifs (Na-O(N):Im-N(O)...

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Bibliographic Details
Published inNucleic acids symposium series (2004) no. 48; pp. 295 - 296
Main Authors Hikishima, Sadao, Kuramoto, Kazuyuki, Minakawa, Noriaki, Matsuda, Akira
Format Journal Article
LanguageEnglish
Published England 2004
Subjects
Base Pairing
Base Sequence
Hydrogen Bonding
Imidazoles - chemistry
Molecular Sequence Data
Naphthyridines - chemistry
Oligodeoxyribonucleotides - chemistry
Oligodeoxyribonucleotides - genetics
Pyridones - chemistry
Pyrimidines - chemistry
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Summary:As our continuing study to develop base pairing motifs which stabilize and regulate DNA structure, we designed novel 1,8-naphthyridine C-nucleosides possessing Na-O(N) and Na-N(O) bases. These C-nucleosides formed two sets of naphthyridine:imidazopyridopyrimidine base pairing motifs (Na-O(N):Im-N(O) and Na-N(O):Im-O(N)) with four hydrogen bonds, and duplexes containing the pairs were markedly thermally stabilized independent of the manner in which the new pairs are incorporated.
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ISSN:1746-8272