Preliminary results of radiosurgery for uveal melanoma

To evaluate the clinical value of stereotactic radiosurgery (SRS) for uveal melanoma. From Jan, 1996 to March, 2004, 16 patients with uveal melanoma were treated with SRS, two by one session (35 Gy, 25 Gy) and fourteen by fractionated SRS (30-55 Gy/2-4F/4-16D). The follow-up period ranged from 3 to...

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Published inZhōnghuá zhŏngliú zázhì Vol. 27; no. 4; p. 241
Main Authors Xiao, Jian-ping, Xu, Guo-zhen, Miao, Yan-jun, Wei, Wen-bin, Hu, Shi-min, Tang, Xin, Wang, Jing-zhao, Wang, Guang-lu
Format Journal Article
LanguageChinese
Published China 01.04.2005
Subjects
Adult
Aged
Eye Enucleation - methods
Female
Humans
Male
Melanoma - surgery
Middle Aged
Radiosurgery
Stereotaxic Techniques
Uveal Neoplasms - surgery
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Summary:To evaluate the clinical value of stereotactic radiosurgery (SRS) for uveal melanoma. From Jan, 1996 to March, 2004, 16 patients with uveal melanoma were treated with SRS, two by one session (35 Gy, 25 Gy) and fourteen by fractionated SRS (30-55 Gy/2-4F/4-16D). The follow-up period ranged from 3 to 100 months (median: 66 months). All 16 patients were still alive though all were blind in the diseased eye during recent follow-up. Local control rate was 93.4%, 5-year survival rate of 13 patients who have been followed for more than 5 years, was 100% (13/13). However, 7 patients received eyeball enucleation due to corneal ulcer (n = 2), suspicion for uncontrolled tumor (n = 2) and secondary glaucoma (n = 3). One patient developed distant metastasis, though still alive. Fractionated radiosurgery is safe and effective for uveal melanoma. It is indicated for lesions of limited size (longest diameter < 20 mm, depth < 15 mm) located in the posterior pole or behind the equator at the back of the eyeball.
ISSN:0253-3766