Central pontine and extrapontine myelinolysis

At the crossover of specialties, the osmotic demyelination syndromes are under-diagnosed clinical entities. Even if the knowledge and the management of these entities have evolved in the latest years, many issues are still unsolved. Initially described as diseases affecting alcoholics and malnourish...

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Published inRevue roumaine de médecine interne (1990) Vol. 46; no. 3; p. 199
Main Authors Tănăsescu, R, Ticmeanu, Marina, Cojocaru, Inimioara Mihaela, Luca, Dimela, Nicolau, Adriana, Hristea, Adriana, Băicuş, C
Format Journal Article
LanguageEnglish
Published Germany 2008
Subjects
Humans
Hyponatremia - complications
Hyponatremia - therapy
Infusions, Intravenous - adverse effects
Myelinolysis, Central Pontine - etiology
Myelinolysis, Central Pontine - physiopathology
Sodium Chloride - administration & dosage
Sodium Chloride - adverse effects
Water-Electrolyte Balance - physiology
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Summary:At the crossover of specialties, the osmotic demyelination syndromes are under-diagnosed clinical entities. Even if the knowledge and the management of these entities have evolved in the latest years, many issues are still unsolved. Initially described as diseases affecting alcoholics and malnourished and considered affecting solely the pons, it is now known that osmotic demyelination can produce extrapontine lesions (extrapontine myelinolysis). Rapid correction of sodium in hyponatremic patients is pathogenically involved in the genesis of central pontine and extrapontine myelinolysis. The aim of this review is to focus on the main characteristics of the disease, which can represent a challenge for the clinicians in respect to its recognition and treatment.
ISSN:1220-4749