Combination of short-period sperm-oocyte coincubation and early rescue intracytoplasmic sperm injection after total failure of in vitro fertilization

To evaluate the outcome of the combination of short-period sperm-oocyte coincubation with early rescue intracytoplasmic sperm injection (ICSI) after complete failure of in vitro fertilization (IVF). We used short-period sperm-oocyte coincubation and overnight fertilization for the oocytes obtained f...

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Bibliographic Details
Published inZhonghua nan ke xue Vol. 15; no. 6; p. 538
Main Authors Zhang, Ning-yuan, Sun, Hai-xiang, Hu, Ya-li, Wang, Bin, Xu, Zhi-peng
Format Journal Article
LanguageChinese
Published China 01.06.2009
Subjects
Adult
Female
Fertilization in Vitro
Humans
Infertility - therapy
Male
Ovum
Pregnancy
Pregnancy Rate
Prospective Studies
Sperm Injections, Intracytoplasmic
Treatment Failure
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Summary:To evaluate the outcome of the combination of short-period sperm-oocyte coincubation with early rescue intracytoplasmic sperm injection (ICSI) after complete failure of in vitro fertilization (IVF). We used short-period sperm-oocyte coincubation and overnight fertilization for the oocytes obtained from 10 IVF-ET cycles, and compared the fertilization results and embryo quality. We conducted polar body observation following short-period sperm-oocyte coincubation for 105 conventional IVF cycles, and evaluated the clinical outcome of early rescue ICSI for total fertilization failure. No significant differences were noted in fertilization outcome and embryo quality between the 3 h short-period and overnight fertilizations (P > 0.05). The combined strategy achieved a clinical pregnancy rate of 53.3%, an implantation rate of 38.0%, with 64 babies born, of whom 44.8% were taken home. The combination of short-period sperm-oocyte coincubation with early rescue ICSI can significantly improve the clinical outcome in pat
ISSN:1009-3591