Hfgl2/fibroleukin expression in liver and peripheral blood mononuclear cells (PBMC) and its correlation with disease severity

• Published in: Zhonghua gan zang bing za zhi Vol. 12; no. 7; p. 385
• Main Authors: Zhu, Fan, Ning, Qin, Chen, Yue, Tao, Xin-Xue, Yan, Wei-Ming, Xi, Dong, Yan, Fu-Ming, Hao, Lian-jie, Luo, Xiao-Ping
• Format: Journal Article
• Language: Chinese
• Published: China 01.07.2004
• Subjects: Adolescent; Adult; Child; Child, Preschool; Female; Fibrinogen - biosynthesis; Fibrinogen - genetics; Hepatitis B, Chronic - metabolism; Hepatitis B, Chronic - pathology; Humans; Infant; Leukocytes, Mononuclear - metabolism; Liver - metabolism; Liver - pathology; Male; Middle Aged; Prognosis; RNA, Messenger - biosynthesis; RNA, Messenger - genetics; Severity of Illness Index; T-Lymphocytes - metabolism
• ISSN: 1007-3418

Viral hepatitis remains a major public health problem and the most common type of liver disease worldwide. There are an increasing number of patients with chronic hepatitis B who develop acute hepatitis on chronic condition (AOC) and die of acute hepatic failure both as a result of lack of understanding of the pathogenesis of the disease and lack of effective treatment. The hallmark of AOC is the extreme rapidity of the necromicroinflammatory process resulting in widespread or total hepatocellular necrosis in weeks or even days. Our previous studies have shown in an experimental animal model of fulminant viral hepatitis caused by murine hepatitis virus strain 3, the importance of macrophage activation, and expression of a unique gene mfgl 2 which encodes a serine protease capable of directly cleaving prothrombin to thrombin, resulting in widespread fibrin deposition within the liver and hepatocyte necrosis. The undergoing study in this report is designed to identify the role of hfgl 2 (human fibrinogen like p