Aike mixture has good anti-inflammatory and analgesic effects on mice

To study the anti-inflammatory and analgesic actions of Aike Mixture (AKM). A total of 100 male mice were randomly assigned into 5 groups: a normal control group, a drug control group (a hydrocortisone subgroup and an atropine subgroup), a high-dose AKM group, a mid-dose AKM group and a low-dose AKM...

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Bibliographic Details
Published inZhonghua nan ke xue Vol. 13; no. 5; p. 471
Main Authors Zhang, Min-jian, Chu, Ke-dan, Cheng, Xin-ling, Pan, Xu-dong, Cheng, Wan-jun, Yu, Kai-yuan, Tan, Yu-hong, Liu, Jin-zhi, Shi, Ya-lei, Zheng, Sheng, Liu, Qiao-bin
Format Journal Article
LanguageChinese
Published China 01.05.2007
Subjects
Animals
Chronic Disease
Disease Models, Animal
Drug Combinations
Male
Mice
Mice, Inbred ICR
Oleanolic Acid - analogs & derivatives
Oleanolic Acid - pharmacology
Oleanolic Acid - therapeutic use
Phytotherapy
Prostatitis - drug therapy
Saponins - pharmacology
Saponins - therapeutic use
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Summary:To study the anti-inflammatory and analgesic actions of Aike Mixture (AKM). A total of 100 male mice were randomly assigned into 5 groups: a normal control group, a drug control group (a hydrocortisone subgroup and an atropine subgroup), a high-dose AKM group, a mid-dose AKM group and a low-dose AKM group. Xylene was spread on the left ear of the experimental mice to induce inflammation, and 1% acetic acid solution injected into the abdominal cavity to produce pain so as to cause the body bend. Different doses of AKM were given and their actions observed. AKM had obvious anti-inflammatory effect on the xylene-induced ear tumefaction and inhibited the pain-caused body bend in the AKM groups, with significant difference from the normal control (P < 0.01). AKM has good anti-inflammatory and analgesic effects, which is of clinical significance in the treatment of chronic prostatitis.
ISSN:1009-3591