Expression of tissue inhibitor of metalloproteinase-1 in colorectal carcinoma and its clinical implications

To investigate the expression and clinical implication of tissue inhibitor of metalloproteinase-1 (TIMP-1) in colorectal carcinoma. TIMP-1 expression in 54 colorectal carcinoma was observed by SP immunohistochemical method, and the results were analyzed in relation to the clinical data of patients....

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Published inNan fang yi ke da xue xue bao = Journal of Southern Medical University Vol. 26; no. 5; p. 699
Main Authors Liu, Yang, Jiang, Bo, Tong, Hua-sheng, Lai, Xiao-rong
Format Journal Article
LanguageChinese
Published China 01.05.2006
Subjects
Adult
Aged
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
Epithelial Cells - chemistry
Epithelial Cells - pathology
Female
Humans
Immunohistochemistry
Lymphatic Metastasis
Male
Middle Aged
Tissue Inhibitor of Metalloproteinase-1 - biosynthesis
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Summary:To investigate the expression and clinical implication of tissue inhibitor of metalloproteinase-1 (TIMP-1) in colorectal carcinoma. TIMP-1 expression in 54 colorectal carcinoma was observed by SP immunohistochemical method, and the results were analyzed in relation to the clinical data of patients. TIMP-1 was localized on the membrane and in the cytoplasm of the enteric epithelial cells, and its expression rate was 100% in normal tissue but only 59.6% (31/52) in colorectal carcinoma tissues. In addition, the expression rate of TIMP-1 was higher in the tumor tissues without lymph node metastasis than in tissues with lymph node metastasis (P<0.05). The expression of TIMP-1 is inversely correlated to lymph node metastasis of colorectal carcinoma, and decreased TIMP-1 expression may play a role in the progression of colorectal carcinoma.
ISSN:1673-4254