A case of metastatic breast cancer with liver metastasis effectively treated with capecitabine and vinorelbine

• Published in: Gan to kagaku ryoho Vol. 36; no. 2; p. 333
• Main Authors: Inari, Hitoshi, Chiba, Akihiko, Inaba, Masaaki, Ino, Hiroyo, Fukahori, Michiko, Yoshida, Akira
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.02.2009
• Subjects: Adult; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Breast Neoplasms - diagnostic imaging; Breast Neoplasms - drug therapy; Breast Neoplasms - pathology; Breast Neoplasms - surgery; Capecitabine; Deoxycytidine - analogs & derivatives; Deoxycytidine - therapeutic use; Female; Fluorouracil - analogs & derivatives; Fluorouracil - therapeutic use; Humans; Liver Neoplasms - diagnostic imaging; Liver Neoplasms - drug therapy; Liver Neoplasms - secondary; Remission Induction; Tomography, X-Ray Computed; Vinblastine - analogs & derivatives; Vinblastine - therapeutic use
• ISSN: 0385-0684

A 31-year-old woman with cancer of the right breast underwent surgery in 1996. Histological examination demonstrated a solid tubular carcinoma that was positive lymph node metastasis and hormonal receptor, but negative for HER2 expression. The patient underwent adjuvant therapy with CAF and tamoxifen. At the age of 40 years old, Multiple liver metastasis appeared to the patient. We treated her with paclitaxel. But multiple liver metastasis became progressive disease. Next we treated with capecitabine and vinorelbine. The liver metastasis reduced, and, in the eighth month, the liver metastasis disappeared after 9 cycles. We changed treatment to goserelin, and anastrozole. The period of complete response was 1 year 3 months.