The effect of surgery with cardiopulmonary bypass on oxygen transport in elderly patients with ischemic heart disease

In a clinical trial, 103 patients undergoing coronary artery bypass grafting from May, 1999, to December, 2001 with hypothermic cardiopulmonary bypass (CPB) were retrospectively assigned to one of two groups: group I (n = 45)--patients 65 years of age and older (68.0 +/- 0.5), group II (n = 58)--pat...

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Bibliographic Details
Published inRossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova Vol. 94; no. 1; p. 53
Main Author Naumenko, S E
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.01.2008
Subjects
Aged
Cardiopulmonary Bypass
Clinical Trials as Topic
Coronary Artery Bypass
Female
Hemodynamics
Humans
Male
Middle Aged
Myocardial Ischemia - metabolism
Myocardial Ischemia - surgery
Oxygen - metabolism
Oxygen Consumption
Postoperative Period
Retrospective Studies
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Summary:In a clinical trial, 103 patients undergoing coronary artery bypass grafting from May, 1999, to December, 2001 with hypothermic cardiopulmonary bypass (CPB) were retrospectively assigned to one of two groups: group I (n = 45)--patients 65 years of age and older (68.0 +/- 0.5), group II (n = 58)--patients 45-50 years of age (48.2 +/- 0.2). The following parameters were recorded: haemodynamic--with thermodilution method (SMU--612, Hellige), blood gases (OMNI-6, Austria). Measurements were performed 7 times: (1) before surgery, (2) before CPB, (3) after CPB, (4, 5, 6, 7)--1, 3, 9, 12 hours after surgery. Indexes of oxygen delivery and consumption, oxygen utilization coefficient and anion gap were calculated. Obtained results were statistically analyzed using appropriate t-test and chi2-test for categorical variables. Data are expressed as mean +/- SE. There were no significant differences between the groups in all stages of examination, p > 0.05. In elderly group both oxygen delivery and consumption were lower then in younger one, thus the coefficient of oxygen utilization did not differ between groups. Therefore the surgery with CPB seems to be inrelated to adverse changes on oxygen transport in elderly patients, and its dynamic was similar in patients over 65 years of age and younger group.
ISSN:0869-8139