Study of differential gene expression in different stage human endometrial cancer

• Published in: Chung-hua fu chʿan kʿo tsa chih Vol. 41; no. 1; p. 38
• Main Authors: Wan, Xiao-ping, Cai, Bin, Liu, Ling, Xi, Xiao-wei, Yang, Yi-xia
• Format: Journal Article
• Language: Chinese
• Published: China 01.01.2006
• Subjects: Carcinoma, Endometrioid - genetics; Carcinoma, Endometrioid - metabolism; Carcinoma, Endometrioid - pathology; Cluster Analysis; Endometrial Neoplasms - genetics; Endometrial Neoplasms - metabolism; Endometrial Neoplasms - pathology; Female; Gene Expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, Neoplasm; Humans; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Oligonucleotide Array Sequence Analysis; Sensitivity and Specificity
• ISSN: 0529-567X

To study the gene expression profile of different stage endometrial cancer and identify genes related to the progression and metastasis of endometrial cancer. cDNA microarray was used to analyze the differentially expressed genes between different stage endometrial cancers. The hierarchical cluster analysis was applied to the gene expression profile of 32 endometrial cancers. Twelve differentially expressed genes were identified between different stage endometrial cancers. The conformity rate was 66% between the result of hierarchical cluster analysis and the operative-histological stages of International Federation of Gynecology and Obstetrics (FIGO). Genes related to the endometrial cancer progression and metastasis can be identified by differential gene expression profile with cDNA microarray and high-risk endometrial cancer may be distinguished before surgery by hierarchical cluster analysis.