The protective effect of high density lipoprotein on the lung function of rats with severe burns

• Published in: Zhonghua shao shang za zhi Vol. 23; no. 4; p. 249
• Main Authors: Zheng, Qing-yi, Hu, An-gen, Zhang, Min-feng, Chen, Jin-he, Cai, Shao-fu, Zheng, Jian-sheng, Zhang, Yang-gen
• Format: Journal Article
• Language: Chinese
• Published: China 01.08.2007
• Subjects: Animals; Blood Gas Analysis; Burns - blood; Burns - pathology; Burns - physiopathology; Intercellular Adhesion Molecule-1 - blood; Lipoproteins, HDL - pharmacology; Lung - drug effects; Lung - pathology; Random Allocation; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha - blood
• ISSN: 1009-2587

To explore the protective effect of high density lipoprotein on the lung function of rats with severe burns. One hundred and thirty-five Wistar rats were employed in the study and were randomly divided into control (n = 15, without injury), burn (n = 60, with 30% TBSA full-thickness burn on the back) and experimental [(n = 60, with the injection of HDL (80 mg/kg) via the caudal vein immediately after burns)] groups. The rats in the latter two groups were resuscitated with intraperitoneal isotonic saline (50 ml/kg) 30 minutes after burns. The serum content of ICAM-1 and TNF-alpha as well as the blood content of PCO2 and PO2 of the rats in burn and experimental groups were determined at 12, 24, 48 and 72 post-burn hours (PBH) and in control group. The pathological changes in the lung tissue of the rats in all groups were observed under light microscope and electronic microscope at 48 PBH. PCO2 and the contents of ICAM-1 and TNF-alpha in burn group were significantly higher, but the PO2 was lower than those in c