Dynamic observation of vascular endothelial growth factor (VEGF)/VEGF-receptors expression in acute leukemia
To investigate the expression of vascular endothelial growth factor (VEGF)/VEGF-receptors and its relation to bone marrow angiogenesis in acute leukemia patients before and after chemotherapy. Bone marrow biopsies from 122 cases with different stages of human acute leukemia were immunostained with a...
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Published in | Chung-hua nei kʿo tsa chih Vol. 43; no. 11; p. 845 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | Chinese |
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China
01.11.2004
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Abstract | To investigate the expression of vascular endothelial growth factor (VEGF)/VEGF-receptors and its relation to bone marrow angiogenesis in acute leukemia patients before and after chemotherapy.
Bone marrow biopsies from 122 cases with different stages of human acute leukemia were immunostained with anti-vascular endothelial growth factor, anti-fms-like tyrosine kinase (Flt-1) and anti- kinase-domain insert containing receptor (KDR) antibodies with envision two-step immunohistochemical staining method.
The expression of VEGF and KDR protein in remission patients was 5.3 (3.3 - 9.0) and 2.0 (1.0 - 4.0) being significantly lower than newly diagnosed untreated patients 6.0 (3.3 - 12.0) and 5.3 (3.3 - 8.0) (P < 0.05, 0.01). However nonsignificant decrease was shown among non-remission patients. In relapsed patients the expression of VEGF and KDR was significantly increased as compared with that in newly diagnosed patients. Flt-1 staining levels were in the same range between the newly diagnosed untreated patients a |
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AbstractList | To investigate the expression of vascular endothelial growth factor (VEGF)/VEGF-receptors and its relation to bone marrow angiogenesis in acute leukemia patients before and after chemotherapy.
Bone marrow biopsies from 122 cases with different stages of human acute leukemia were immunostained with anti-vascular endothelial growth factor, anti-fms-like tyrosine kinase (Flt-1) and anti- kinase-domain insert containing receptor (KDR) antibodies with envision two-step immunohistochemical staining method.
The expression of VEGF and KDR protein in remission patients was 5.3 (3.3 - 9.0) and 2.0 (1.0 - 4.0) being significantly lower than newly diagnosed untreated patients 6.0 (3.3 - 12.0) and 5.3 (3.3 - 8.0) (P < 0.05, 0.01). However nonsignificant decrease was shown among non-remission patients. In relapsed patients the expression of VEGF and KDR was significantly increased as compared with that in newly diagnosed patients. Flt-1 staining levels were in the same range between the newly diagnosed untreated patients a |
Author | Wang, Chen Xu, Yan-Ping Ouyang, Ren-Rong Chen, Fang-Yuan Han, Jie-Ying Zhu, Jian-Shan |
Author_xml | – sequence: 1 givenname: Chen surname: Wang fullname: Wang, Chen email: pattywang@tom.com organization: Deparmant of Leukemia Research, Shanghai Institute of Hematology, Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China. pattywang@tom.com – sequence: 2 givenname: Fang-Yuan surname: Chen fullname: Chen, Fang-Yuan – sequence: 3 givenname: Jian-Shan surname: Zhu fullname: Zhu, Jian-Shan – sequence: 4 givenname: Yan-Ping surname: Xu fullname: Xu, Yan-Ping – sequence: 5 givenname: Jie-Ying surname: Han fullname: Han, Jie-Ying – sequence: 6 givenname: Ren-Rong surname: Ouyang fullname: Ouyang, Ren-Rong |
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SubjectTerms | Adolescent Adult Aged Aged, 80 and over Bone Marrow - blood supply Bone Marrow - metabolism Female Humans Immunohistochemistry Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - metabolism Male Middle Aged Neovascularization, Pathologic Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor Receptor-1 - metabolism Vascular Endothelial Growth Factor Receptor-2 - metabolism |
Title | Dynamic observation of vascular endothelial growth factor (VEGF)/VEGF-receptors expression in acute leukemia |
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