Safety issues of traditional Chinese medical preparations containing arsenic substances: review starting from Niuhuang Jiedu Pian (Wan)

By comprehensively reviewing the origin and history of Niuhuang Jiedu Wan and its "derivatives", we studied the clinical records of realgar, investigated its clinical usage, dosage, efficacy, and toxicity in the literatures. We pinpointed the factors that might be associated with safety pr...

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Bibliographic Details
Published inZhongguo zhongyao zazhi Vol. 31; no. 23; p. 2010
Main Authors Zhang, Li, Gao, Si-Hua, Zhou, Chao-fan, Lin, Rui-chao, Liu, Chang-hua
Format Journal Article
LanguageChinese
Published China 01.12.2006
Subjects
Arsenic Poisoning - history
Arsenic Poisoning - prevention & control
Arsenicals - adverse effects
Arsenicals - analysis
Arsenicals - history
Drug Combinations
History, 20th Century
History, 21st Century
History, Ancient
History, Medieval
Humans
Medicine, Chinese Traditional
Sulfides - adverse effects
Sulfides - analysis
Sulfides - history
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Summary:By comprehensively reviewing the origin and history of Niuhuang Jiedu Wan and its "derivatives", we studied the clinical records of realgar, investigated its clinical usage, dosage, efficacy, and toxicity in the literatures. We pinpointed the factors that might be associated with safety problems of Niuhuang Jiedu Pian (Wan) and other traditional Chinese medicine (TCM) preparations containing arsenic substances. In this article we also put forward suggestions for strengthening the surveillance and administration of similar TCM preparations.
ISSN:1001-5302