Expressions of vascular endothelial growth factor C and matrix metalloproteinases-2 and prognosis of non-small cell lung carcinoma

• Published in: Nan fang yi ke da xue xue bao = Journal of Southern Medical University Vol. 26; no. 9; p. 1307
• Main Authors: Zhang, Hui-zhong, Wei, Yi-ping, Li, Hai-gang, Wang, Mei, Liu, Jin-geng, Wu, Cheng
• Format: Journal Article
• Language: Chinese
• Published: China 01.09.2006
• Subjects: Adult; Aged; Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Non-Small-Cell Lung - pathology; Female; Humans; Immunohistochemistry; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Lymphatic Metastasis; Male; Matrix Metalloproteinase 2 - biosynthesis; Middle Aged; Prognosis; Survival Analysis; Vascular Endothelial Growth Factor C - biosynthesis
• ISSN: 1673-4254

To investigate the expressions of vascular endothelial growth factor-C (VEGF-C) and matrix metalloproteinases-2 (MMP-2) proteins and its relationship with the biological behaviors of non-small cell lung carcinoma (NSCLC). Immunohistochemical staining was used to detect the expressions of VEGF-C and MMP-2 proteins in 42 cases of NSCLC tissues. The relationship of VEGF-C and MMP-2 expressions was analyzed with the tumor size, lymphatic vessel density (LVD), histological type, differentiation, clinical recurrence, lymph node metastasis and patients' survival time. Out of the 42 cases of NSCLC, 23 and 26 cases showed positive expressions of VEGF-C and MMP-2 proteins, respectively, with the expression rates of VEGF-C and MMP-2 protein of 54.8% and 61.9%, respectively. VEGF-C expression was positively associated with LVD and lymph node metastasis (P<0.05), and inversely with the differentiation of NSCLC and the patients' survival time (P<0.05). MMP-2 expression was positively associated with lymph node metastasis (