Value of proton magnetic resonance spectroscopy with two-dimensional chemical-shift imaging in evaluating brain gliomas

• Published in: Nan fang yi ke da xue xue bao = Journal of Southern Medical University Vol. 28; no. 8; p. 1342
• Main Authors: Zhou, Gao-feng, Wang, Xiao-yi, Gong, Cai-gui, Liu, Fan, Wang, Run-wen
• Format: Journal Article
• Language: Chinese
• Published: China 01.08.2008
• Subjects: Adolescent; Adult; Aged; Brain Neoplasms - diagnosis; Female; Glioma - diagnosis; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging - methods; Magnetic Resonance Spectroscopy - methods; Male; Middle Aged; Young Adult
• ISSN: 1673-4254

To study the value of proton magnetic resonance spectroscopy ((1)H-MRS) with two-dimensional (2D) chemical-shift imaging (CSI) in evaluating brain gliomas. Thirty-six patients with gliomas received examinations with 2D-CSI. The VOI of MRS included the tumor, peritumoral edematous and nonedematous areas, and the contralateral normal tissue. The changes of the metabolites in different areas were determined using 2D-CSI (1)H-MRS with SE sequence and the metabolite ratios were calculated. Significant differences were found in the ratios of NAA/Cr, Cho/Cr and NAA/Cho between low-grade gliomas and contralateral normal brain tissue, and between high-grade gliomas and the contralateral normal tissue (P<0.01). The low-grade gliomas and high-grade gliomas differed significantly in the ratios of NAA/Cr, Cho/Cr and NAA/Cho (P<0.05). These ratios also showed significant differences between peritumoral edematous area and the glioma tissue, between the peritumoral edematous area and contralateral normal brain tissue (P<0.05