Development of new Japanese encephalitis vaccine

We have developed the new inactivated Japanese encephalitis vaccine derived from virus-infected Vero cells cultured on microcarriers. The safety and effectiveness of this new vaccine were compared with those of current mouse-brain-derived vaccine that have some intrinsic demerits such as possible co...

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Bibliographic Details
Published inNihon rinshō Vol. 63; no. 12; p. 2133
Main Author Ishikawa, Toyokazu
Format Journal Article
LanguageJapanese
Published Japan 01.12.2005
Subjects
Animals
Encephalitis, Japanese - prevention & control
Humans
Infant
Japanese Encephalitis Vaccines
Male
Mice
Safety
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Summary:We have developed the new inactivated Japanese encephalitis vaccine derived from virus-infected Vero cells cultured on microcarriers. The safety and effectiveness of this new vaccine were compared with those of current mouse-brain-derived vaccine that have some intrinsic demerits such as possible contamination of adventitious agents. The results of pre-clinical and clinical trials suggested that the safety and effectiveness of new vaccine are approximate equivalent to those of currently conventional vaccine in humans and animals, and that the availability of Vero cell-derived vaccine is anticipated.
ISSN:0047-1852