Sivelestat sodium hydrate improves septic acute lung injury by reducing alveolar dysfunction

Sivelestat sodium hydrate (sivelestat) is a selective inhibitor of polymorphonuclear leukocyte elastase (PMN-E). We administered sivelestat to patients with septic acute lung injury (ALI) to examine its usefulness. The primary endpoints in the study were the duration of artificial ventilation and pu...

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Bibliographic Details
Published inResearch communications in molecular pathology and pharmacology Vol. 119; no. 1-6; p. 53
Main Authors Endo, Shigeatsu, Sato, Nobuhiro, Yaegashi, Yasunori, Suzuki, Yasushi, Kojika, Masahiro, Yamada, Yasuhiko, Yoshida, Yuki, Nakadate, Toshihide, Aoki, Hidehiko, Inoue, Yoshihiro
Format Journal Article
LanguageEnglish
Published United States 2006
Subjects
Acute Disease
Adolescent
Adult
Aged
Glycine - administration & dosage
Glycine - analogs & derivatives
Glycine - therapeutic use
Humans
Interleukin-8 - blood
Leukocyte Elastase - antagonists & inhibitors
Leukocyte Elastase - blood
Leukocytes - drug effects
Middle Aged
Oxygen - blood
Pulmonary Circulation - drug effects
Pulmonary Surfactant-Associated Protein D - blood
Respiration, Artificial - statistics & numerical data
Serine Proteinase Inhibitors - administration & dosage
Serine Proteinase Inhibitors - therapeutic use
Sulfonamides - administration & dosage
Sulfonamides - therapeutic use
Survival Analysis
Systemic Inflammatory Response Syndrome - drug therapy
Systemic Inflammatory Response Syndrome - immunology
Treatment Outcome
Tumor Necrosis Factor-alpha - blood
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Summary:Sivelestat sodium hydrate (sivelestat) is a selective inhibitor of polymorphonuclear leukocyte elastase (PMN-E). We administered sivelestat to patients with septic acute lung injury (ALI) to examine its usefulness. The primary endpoints in the study were the duration of artificial ventilation and pulmonary oxygenation ability, and the secondary endpoints were mortality and the concentrations of PMN-E, SP-D, TNF-alpha and IL-8 in blood. In the sivelestat group, the duration of artificial ventilation, pulmonary oxygenation ability, and the blood PMN-E, SP-D, TNF-alpha and IL-8 concentrations decreased significantly. Administration of sivelestat was found to reduce alveolar dysfunction and improve respiratory function, and it was suggested that early administration might be useful.
ISSN:1078-0297