Shared donor oocyte system to determine if top embryos can be derived from oocyte factors or more likely from an oocyte/sperm interaction

To determine if top embryos require an unusual, and possibly fortuitous, combination of excellent oocyte quality and sperm, or whether some oocyte property alone leads to the formation of superior quality embryos on day 3. The embryo quality of donor oocyte recipient cycles was evaluated to find a w...

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Bibliographic Details
Published inClinical and experimental obstetrics & gynecology Vol. 31; no. 4; p. 265
Main Authors Horwath, D, Check, J H, Choe, J K, Summers-Chase, D, Krotec, J W
Format Journal Article
LanguageEnglish
Published Canada 2004
Subjects
Adult
Embryo Transfer
Embryo, Mammalian - physiology
Female
Humans
Infertility, Female - therapy
Male
Oocyte Donation - methods
Pregnancy
Pregnancy Outcome
Spermatozoa - physiology
Twins
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Summary:To determine if top embryos require an unusual, and possibly fortuitous, combination of excellent oocyte quality and sperm, or whether some oocyte property alone leads to the formation of superior quality embryos on day 3. The embryo quality of donor oocyte recipient cycles was evaluated to find a woman who made 100% top embryos. After finding such an individual, the quality of the recipient's embryos was also evaluated. The shared donor oocyte recipient cycles were also evaluated for pregnancy outcome. All 15 embryos were graded top. The six embryos transferred to the donor and recipient resulted in two sets of triplets. One of the fetuses of the recipient aborted related to trisomy 21. The data indicates that the formation of an extremely high percentage (100%) of top embryos can be related to an oocyte factor. It is extremely unlikely to find two male partners who produce sperm with a unique property that makes superior morphologic embryos implant.
ISSN:0390-6663