Study on the variation of platelet function in pregnancy induced hypertension and gestational diabetes mellitus

• Published in: Chung-hua fu chʿan kʿo tsa chih Vol. 40; no. 1; p. 25
• Main Authors: Yin, Song-mei, Li, Yi-qing, Xie, Shuang-feng, Ma, Li-ping, Wu, Yu-dan, Nie, Da-nian, Feng, Jian-hong, Xu, Li-zhuo
• Format: Journal Article
• Language: Chinese
• Published: China 01.01.2005
• Subjects: Adult; Blood Platelets - physiology; Diabetes, Gestational - blood; Female; Flow Cytometry; Humans; Hypertension, Pregnancy-Induced - blood; Platelet Activation; Platelet Count; Platelet Membrane Glycoproteins - biosynthesis; Pregnancy
• ISSN: 0529-567X

To investigate the platelet activity and function in pregnancy induced hypertension (PIH) and gestational diabetes mellitus (GDM). Twenty-one patients with GDM and 23 patients with PIH in third-trimester were included. Twenty normal pregnant women in third-trimester served as controls. Platelet count (PC), mean platelet volume (MPV) were determined on Cell-DYN 1600 and the expression of CD62P was analyzed on FACSC alibur. (1) PC was (181 +/- 56) x 10(9)/L in PIH, (206 +/- 60) x 10(9)/L in GDM and (229 +/- 56) x 10(9)/L in controls, respectively. PC in PIH was lower than that of controls (P < 0.01), but there was no significant difference between GDM and controls. (2) MPV was (11.2 +/- 2.0) fl in PIH, significantly higher than that of controls (8.7 +/- 1.6) fl (P < 0.001). In GDM, MPV was (9.5 +/- 1.6) fl, without significant difference compared with that of controls. (3) The expression of CD62P increased significantly in PIH compared with controls [CD62P: (42 +/- 13)% vs (26 +/- 7)%, P < 0.001; CD62P(I): 109