Effect of heparin on fetal growth restriction

• Published in: Chung-hua fu chʿan kʿo tsa chih Vol. 39; no. 12; p. 793
• Main Authors: Yu, Yan-hong, Shen, Li-yong, Zhong, Mei, Zhang, Yu, Su, Gui-dong, Gao, Yun-fei, Quan, Song, Zeng, Li
• Format: Journal Article
• Language: Chinese
• Published: China 01.12.2004
• Subjects: Birth Weight - drug effects; Female; Fetal Growth Retardation - diagnostic imaging; Fetal Growth Retardation - drug therapy; Fetal Growth Retardation - pathology; Heparin - therapeutic use; Heparin, Low-Molecular-Weight - therapeutic use; Humans; Infant, Newborn; Placenta - blood supply; Pregnancy; Ultrasonography, Doppler, Color; Ultrasonography, Prenatal - methods
• ISSN: 0529-567X

To investigate the clinical effect and safety of heparin in treating fetal growth restriction (FGR). A total of 107 women diagnosed with FGR were randomized into three groups. Group 1 (standard heparin group, n = 37) received 50 - 75 mg standard heparin added to 500 ml 5% glucose sodium chloride, infused intravenously in 6 - 8 hours. Group 2 (low molecular weight heparin group, n = 31) received 0.2 - 0.4 ml low molecular weight heparin given by subcutaneous injection. Control group (n = 39) received 20 ml dan-shen added to 500 ml low-molecular-weight dextran infused intravenously. Fetal growth indices, biophysical score, umbilical artery blood flow, count of platelet (PLT), prothrombin time (PT), activated partial thromboplastin time (APTT), 1-minute Apgar score, body weight and gestational age of the neonates were measured. Babies prognosis was followed-up. (1) Height of fundus of uterus was obviously increased per week in the groups of standard heparin (0.7 +/- 0.6) cm and low molecular weight heparin [(0.7