Protective effects of ulinastatin against multiple organic damage after severe burn injury: experimental and clinic studies

• Published in: Zhong hua yi xue za zhi Vol. 85; no. 41; p. 2889
• Main Authors: Hu, Xiao-hua, Zhang, Hui-ying, Ge, Yan-ling, Chen, Zhong, Qin, Feng-jun, Jiang, Hai-yan, Chen, Da-fu, Sun, Yong-hua
• Format: Journal Article
• Language: Chinese
• Published: China 02.11.2005
• Subjects: Adolescent; Adult; Animals; Burns - blood; Burns - complications; Burns - drug therapy; Female; Glycoproteins - therapeutic use; Humans; Interleukin-6 - blood; Lipopolysaccharides - blood; Male; Middle Aged; Multiple Organ Failure - blood; Multiple Organ Failure - prevention & control; Protective Agents - therapeutic use; Superoxide Dismutase - blood; Swine; Swine, Miniature; Trypsin Inhibitors - therapeutic use; Tumor Necrosis Factor-alpha - blood
• ISSN: 0376-2491

To study the protective effects of ulinastatin (UTI), a human trypsin inhibitor, on the damage to the functions of multiple organs at the early stage of severe burn. (1) Twelve male mini-pigs, inflicted with III degrees burn with 35% total body surface area (TBSA), were randomly divided into two equal groups: Group A (control group, treated with fluid resuscitation immediately after injury and normal saline by intravenous drip tid) and Group B (UTI-treated group, in addition to fluid resuscitation UTI 5000 U/kg was given one hour after injury, 3 times/day). Blood samples were taken for the determination of serum TNF-alpha, IL-6, malonyldiadehyde (MDA), superoxide dismutase (SOD), alanine transaminase (ALT), aspartate transaminase (AST), creatine kinase (CK), MB isoenzyme of CK (CK-MB), blood urea nitrogen (BUN), creatinine (Cr), diamine oxidase (DAO), and D-lactate before and 6, 24, 48, and 72 hours after injury. (2) Forty hospitalized patients with 50%-70% TBSA partial and full thickness burn, 28 males and 1