Incidence of the gene cagA and amount of microbial bodies of Helicobacter pylori in biopsy materials--what is the correlation?

• Published in: Ėksperimental'nai͡a︡ i klinicheskai͡a︡ gastroėnterologii͡a no. 4; p. 22
• Main Authors: Kamneva, N V, Panov, A N
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2006
• Subjects: Antigens, Bacterial - genetics; Bacterial Proteins - genetics; Biopsy; DNA, Bacterial - analysis; Duodenal Ulcer - diagnosis; Duodenal Ulcer - microbiology; Duodenal Ulcer - pathology; Female; Helicobacter Infections - complications; Helicobacter Infections - diagnosis; Helicobacter Infections - microbiology; Helicobacter pylori - genetics; Helicobacter pylori - isolation & purification; Helicobacter pylori - pathogenicity; Humans; Male; Polymerase Chain Reaction; Stomach Ulcer - diagnosis; Stomach Ulcer - microbiology; Stomach Ulcer - pathology; Virulence - genetics
• ISSN: 1682-8658

The study objective was to determine the correlation between the incidence of cagA gene of Helicobacter pylori (H. pylori) and the quantity of microbial bodies of H. pylori in biopsy materials of the gastric mucous coat. As many as 85 patients with duodenal ulcer (DU), 52 patients with gastric ulcer (GU), 41 patients with atrophic gastritis (AG) and 53 patients with post-resection syndrome (PRS) were examined. Statistically significant results revealed weak correlation in patients with AG and PRS and medium correlation for patients with DU and GU. Therefore, the count of microbial bodies of H. pylori in biopsy materials as the method for predicting the presence of cagA gene in H. pylori can be used only in cases when the gastric secretion is decreased, i.e. for patients with AG and PRS.