Study of a relationship between a change in the urinary uracil value after a S-1 long-term administration and the recurrence of stomach cancer

S-1 has been reported good results in the treatment of stomach cancer. However, a DPD activity change has also been reported as one of the causes for a recurrence though some recurrence cases observing a state of tumor being unchanged continuously for more than 1 year. Therefore the urinary uracil v...

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Bibliographic Details
Published inGan to kagaku ryoho Vol. 35; no. 6; p. 947
Main Authors Morimoto, Shigefumi, Tsuji, Takeshi, Shono, Yoshiharu, Akiyama, Isao, Fujita, Yoshikazu, Hasegawa, Kenji, Tabuse, Katsuyoshi
Format Journal Article
LanguageJapanese
Published Japan 01.06.2008
Subjects
Aged
Drug Combinations
Female
Health
Humans
Male
Middle Aged
Oxonic Acid - administration & dosage
Oxonic Acid - therapeutic use
Recurrence
Stomach Neoplasms - drug therapy
Stomach Neoplasms - pathology
Stomach Neoplasms - urine
Tegafur - administration & dosage
Tegafur - therapeutic use
Time Factors
Uracil - urine
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Summary:S-1 has been reported good results in the treatment of stomach cancer. However, a DPD activity change has also been reported as one of the causes for a recurrence though some recurrence cases observing a state of tumor being unchanged continuously for more than 1 year. Therefore the urinary uracil value, which could simply be predicted in the DPD activity at the time of a recurrence after having administered S-1 for a long-term, was measured. And the urinary uracil value was examined whether it could become an index of recurrence compared with a healthy 5-person example as reference. In the result, a monthly difference in change of the urinary uracil values of the reference was small. However, the urinary uracil values in patients who were administered S-1 more than 6 months but recurred, were significantly lower comparing with the healthy 5-person example. We concluded from this study that the change in DPD activity due to an induction of DPD by 5-FU and metastasis of cancer caused the recurrence and lower a urinary value. The urinary uracil value reflecting DPD activity of the whole body could be used as an index of recurrence at the time of long-term dosage of S-1. Furthermore, a measurement of the urinary uracil value seems to be promising for estimation and evaluation of the cure.
ISSN:0385-0684