The protective effect of aloe vera juice on lindane induced hepatotoxicity and genotoxicity

The protective effect of fresh aloe vera (AV) leaves extract on lindane (LD) - induced hepatoxicity and genotoxicity was studied. Serum levels of hepatic enzyme markers: glutamate pyruvate transaminase (GPT), glutamate oxaloacetate transaminase (GOT), gamma glutamyl transferase (GGT) and alkaline ph...

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Bibliographic Details
Published inPakistan journal of pharmaceutical sciences Vol. 19; no. 4; p. 337
Main Authors Etim, O E, Farombi, E O, Usoh, I F, Akpan, E J
Format Journal Article
LanguageEnglish
Published Pakistan 01.10.2006
Subjects
Aloe
Animals
Erythrocytes - drug effects
Female
Lindane - toxicity
Liver - drug effects
Micronucleus Tests
Plant Extracts - pharmacology
Rats
Rats, Wistar
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Summary:The protective effect of fresh aloe vera (AV) leaves extract on lindane (LD) - induced hepatoxicity and genotoxicity was studied. Serum levels of hepatic enzyme markers: glutamate pyruvate transaminase (GPT), glutamate oxaloacetate transaminase (GOT), gamma glutamyl transferase (GGT) and alkaline phosphatase (ALP) were determined after oral administration of aloe vera leaves extract and lindane. The level of polychromatic erythrocytes was also observed. Pretreatment with aloe vera leaves extract at concentration of 1.0 ml/kg body weight significantly decreased (P<0.05) the serum levels of GPT (by 41.8%), GOT (by 36.5%), GGT (by 14.3%) and ALP (by 10.7%) induced by 100mg/kg body weight of lindane. The level of polychromatic erythrocytes observed was not statistically significant when compared to control.
ISSN:1011-601X