Characteristics of TCM syndrome and appraisal with echocardiography in heart failure rats after myocardial infarction

• Published in: Zhongguo Zhong xi yi jie he za zhi Vol. 27; no. 3; p. 227
• Main Authors: Wu, Ai-ming, Zhao, Ming-jing, Zhang, Dong-mei
• Format: Journal Article
• Language: Chinese
• Published: China 01.03.2007
• Subjects: Animals; Diagnosis, Differential; Echocardiography, Doppler; Heart Failure - diagnosis; Heart Failure - diagnostic imaging; Heart Failure - etiology; Male; Medicine, Chinese Traditional; Myocardial Infarction - complications; Random Allocation; Rats; Rats, Sprague-Dawley; Syndrome; Ventricular Dysfunction, Left - diagnosis; Ventricular Dysfunction, Left - diagnostic imaging; Ventricular Dysfunction, Left - etiology
• ISSN: 1003-5370

To study the characteristics of the TCM syndrome and the changes of ventricular structure and function in heart failure (HF) rats after- myocardial infarction (MI). Rats were randomly divided in to the model group and the sham-operative group. The HF rat with MI model was induced by ligation of the left coronary artery. Eight weeks after operation, appraisal on TCM syndrome revealed in the model was made from the aspects of general status, breathing frequency, heart rate, exhausting swimming time and electrocardiogram, and left ventricular structure and function were observed with echocardiography. Eight weeks after operation, as compared with those in the sham group, in the model group, the heart rate and breathing frequency were accelerated, the exhausting swimming time shortened, the echocardiogram parameters such as interventricular septum end-diastole thickness (IVSTd), posterior wall end-diastole thickness (PWTd), posterior wall end-systolic thickness (PWTs), ejection fraction (EF) and fractional shorte