The effects of antiarrhythmic peptide AAP10 on ventricular arrhythmias in rabbits with healed myocardial infarction

• Published in: Zhōnghuá xīnxuèguănbìng zázhì Vol. 34; no. 9; p. 825
• Main Authors: Ren, Yong, Zhang, Cun-tai, Wu, Jie, Ruan, Yan-fei, Pu, Jun, He, Li, Wu, Wei, Chen, Bai-di, Wang, Wen-guang, Wang, Lin
• Format: Journal Article
• Language: Chinese
• Published: China 01.09.2006
• Subjects: Animals; Arrhythmias, Cardiac - etiology; Arrhythmias, Cardiac - prevention & control; Male; Myocardial Infarction - complications; Myocardial Infarction - physiopathology; Oligopeptides - pharmacology; Rabbits; Random Allocation
• ISSN: 0253-3758

To evaluate the effects of antiarrhythmic peptide (AAP10) on ventricular arrhythmias in rabbits with healed myocardial infarction (OMI). Thirty rabbits were randomly divided into three groups (n = 10 each): Sham group, left thoracotomy was performed without coronary ligation; OMI group and OMI + AAP10 group, the circumflex coronaries were ligated. Three months post operation, the electrophysiological and antiarrhythmic effects of AAP10 were assessed in the arterially perfused rabbit left ventricular wedge preparation. Sham and OMI group were perfused with Tyrode's solution and OMI + AAP10 group was perfused with Tyrode's solution + AAP10 (80 nmol/L). Transmembrane action potentials were recorded simultaneously from endocardium and epicardium together with a transmural ECG by use of 2 separate intracellular floating microelectrodes. The stimulus-response-interval (SRI) of the epicardium and the incidence of ventricular tachycardia (VT) were observed. Whole heart and left ventricular weights, the left ventricul