Expressions of vascular endothelial growth factor and nm23-H1 gene and their relation to the prognosis of breast cancer in young women

• Published in: Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA Vol. 24; no. 12; p. 1398
• Main Authors: Huang, Zong-hai, Su, Guo-qiang, Mao, Qian-guo, Wang, Qin-zhi, Li, Zhou, Yu, Jin-long, Fan, Ying-fang
• Format: Journal Article
• Language: Chinese
• Published: China 01.12.2004
• Subjects: Adult; Age Factors; Aged; Breast Neoplasms - metabolism; Female; Humans; Lymphatic Metastasis; Middle Aged; NM23 Nucleoside Diphosphate Kinases; Nucleoside-Diphosphate Kinase - biosynthesis; Nucleoside-Diphosphate Kinase - genetics; Prognosis; Vascular Endothelial Growth Factor A - biosynthesis; Vascular Endothelial Growth Factor A - genetics
• ISSN: 1000-2588

To investigate the expressions of vascular endothelial growth factor (VEGF) and nm23-H1 gene in breast cancer tissues and their relation to the prognosis in young women. The expressions of VEGF and nm23-H1 gene were detected using immunohistochemical method (SP) in the breast cancer tissues of 48 young and 30 postmenopausal women with breast cancer and in breast fibroadenoma tissues of 10 patients for analysis of the association of the expressions with the patients' clinical and pathological characteristics, with also observation of the 5-year survival rate in each patient group. The rates of axillary lymph node metastasis was higher in the young women than in the postmenopausal women, who also had significantly different rates of VEGF and nm23-H1 expressions in the breast cancer tissues (P<0.01, P<0.01 and P<0.05, respectively); between the two breast cancer groups and breast fibroadenoma group, the expressions were also different (P<0.01). In both young and postmenopausal women with breast cancer, patients