Withdrawal symptoms of ethanol are ameliorated by thymopentin in mice

• Published in: Beijing da xue xue bao. Journal of Peking University. Yi xue ban Vol. 37; no. 6; p. 641
• Main Authors: Han, Xue-lian, Xu, Min, Xu, De-yi
• Format: Journal Article
• Language: Chinese
• Published: China 18.12.2005
• Subjects: Adjuvants, Immunologic - therapeutic use; Animals; Anxiety - chemically induced; Anxiety - prevention & control; Ethanol - administration & dosage; Ethanol - toxicity; Male; Mice; Random Allocation; Substance Withdrawal Syndrome - prevention & control; Substance Withdrawal Syndrome - psychology; Thymopentin - therapeutic use
• ISSN: 1671-167X

To explore the effect of thymopentin (TP5) on the choice of ethanol and ameliorating withdrawal symptoms (anxiety) of ethanol in mice. Mice were administered ethanol (v/v) in schedular fashion: 5% (1 week), 10% (1 week) and 15% (4 weeks), followed with the free choice between ethanol and water. Ethanol/(ethanol+water)x100% [E/(E+W)x100%] was measured as an index of ethanol selection. Light-dark box test and elevated plus maze test were chosen for the assessment of anxiety pre-drug and post-drug. After TP5 [0.2 mg/(kgxd), 0.4 mg/(kgxd)], i.p. or saline (vehicle control), i.p. for 14 days, the procedure was repeated. (1) E/(E+W)x100%: the post-drug values of TP5 (0.2 mg/kg, 0.4 mg/kg) were lower significantly than the pre-drug values. (2) Light-dark box test: the post-drug values of number of entries and time spent in the light chamber of TP5 (0.2 mg/kg, 0.4 mg/kg) were more than the pre-drug values themselves and the post-drug value of saline. (3) Elevated plus maze test: the post-drug values of time spent on