Cardioprotective effects of propofol and midazolam in children with congenital heart diseases undergoing open heart surgery

• Published in: Zhong hua yi xue za zhi Vol. 87; no. 33; p. 2309
• Main Authors: Zou, Han-dong, Zhou, Qing-shan, Xia, Wen-fang, Wu, Ling-xi, Cheng, Bang-chang
• Format: Journal Article
• Language: Chinese
• Published: China 04.09.2007
• Subjects: Adolescent; Anesthetics, Intravenous - administration & dosage; Body Temperature - drug effects; Cardiac Surgical Procedures - methods; Cardiotonic Agents - administration & dosage; Child; Child, Preschool; Electrocardiography - drug effects; Extracorporeal Circulation; Heart Defects, Congenital - surgery; Heme Oxygenase-1 - metabolism; Humans; Midazolam - administration & dosage; Propofol - administration & dosage; Troponin I - blood
• ISSN: 0376-2491

To observe the cardioprotective effects of propofol and midazolam in children with congenital heart diseases undergoing open heart surgery. Thirty-two children with cyanotic congenital heart diseases of ASA classes I - II were randomly divided into 2 equal groups: propofol combined with low dose fentanyl group (Group PF) and midazolam combined with low dose fentanyl group (Group MF). The changes of hemodynaics, ECG, SpO2, nasopharyngeal and rectal temperatures were monitored continuously. The time of tracheal extubation and ICU staying time were recorded. Venous blood samples were collected when the venous channel was opened (T(0)), 2 h after declamping of the aorta (T(4)), and 24 h after operation (T(5)) to detect the plasma cardiac troponin I (cTnI). Myocardium samples were collected 10 - 20 min after aorta cross-clamp (T(2)), and 10 - 20 min after declamping of the aorta (T(3)) to undergo immunohistochemistry to observe the expression of heme oxygenase-1 (HO-1). The tracheal time of Group GF was 14.17 h, s