Expression and correlation of apoptosis-related gene c-IAP2 and caspase-4 in sinonasal squamous carcinoma

To examine the expression of apoptosis-related genes c-IAP2 and caspase-4 in sinonasal squamous carcinoma. To investigate the role and mechanism of the two apoptosis-related genes in nasal cavity and sinus squamons carcinoma. Forty-one pathologically confirmed specimens of nasal cavity and sinus squ...

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Bibliographic Details
Published inZhonghua er bi yan hou ke za zhi Vol. 39; no. 6; p. 324
Main Authors Li, Hui, Zeng, Zi-Hua, Wang, Li-Hua, Wang, Ji-Qun
Format Journal Article
LanguageChinese
Published China 01.06.2004
Subjects
Adult
Aged
Carcinoma, Squamous Cell - metabolism
Caspases - biosynthesis
Caspases, Initiator
Female
Humans
Male
Middle Aged
Nose Neoplasms - metabolism
Paranasal Sinus Neoplasms - metabolism
Proteins - metabolism
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Summary:To examine the expression of apoptosis-related genes c-IAP2 and caspase-4 in sinonasal squamous carcinoma. To investigate the role and mechanism of the two apoptosis-related genes in nasal cavity and sinus squamons carcinoma. Forty-one pathologically confirmed specimens of nasal cavity and sinus squamons carcinoma were subjected for immunohistochemical staining to analyze the expression of c-IAP2 and caspase-4, in addition 10 normal nasal mucosa were used as control. The positive rate of c-IAP2 in sinonasal squamons carcinoma was 87.8%, among which 14 cases were strongly stained(+ + +), 15 cases were stained(+ +), 7 cases were stained (+), only 5 cases were negative. In 10 normal control tissues, no case was stained(+ + +), 2 cases were stained (+ +), 3 cases were stained(+), the other 5 cases were negative. Higher level expression of c-IAP2 protein was detected more often in squamons carcinoma specimens than that in normal nasal mucosa. There was statistically significant difference between the two groups fo
ISSN:0412-3948