Clinical study on effect of tongluo capsule in treating diabetic nephropathy caused chronic renal failure

• Published in: Zhongguo Zhong xi yi jie he za zhi Vol. 24; no. 8; p. 704
• Main Authors: Sun, Wan-sen, Wu, Xi-li, Qiao, Cheng-lin
• Format: Journal Article
• Language: Chinese
• Published: China 01.08.2004
• Subjects: Adult; Albuminuria - drug therapy; Blood Urea Nitrogen; Capsules; Creatinine - blood; Diabetic Nephropathies - complications; Diabetic Nephropathies - drug therapy; Drugs, Chinese Herbal - therapeutic use; Female; Humans; Kidney Failure, Chronic - drug therapy; Kidney Failure, Chronic - etiology; Lipids - blood; Male; Middle Aged; Phytotherapy; Tongue; Transforming Growth Factor beta - blood; Transforming Growth Factor beta1
• ISSN: 1003-5370

To observe the therapeutic effect of Tongluo capsule (TLC) in treating diabetic nephropathy (DN) complicated chronic renal failure (CRF), and to explore its mechanism preliminarily. Ninety-seven patients with DN-CRF were randomly divided into the TCM group (n = 50) and the WM group (n = 47) to observe the changes of urinary protein per 24 hrs (UP/24h), renal function, creatinine (Cr), blood urea nitrogen (BUN), blood lipids (TG, TC, HDL-C, LDL-C) and serum transforming growth factor-beta1 (TGF-beta1) before and after treatment. After 6 months of treatment, levels of UP/24h, Cr, BUN and TGF-beta1 significantly lowered in both groups (P<0.01), and a better effect was showed in the TCM group in aspects of lowering Cr, BUN and TGF-beta1 (P<0.01). Besides, TLC also showed effect in lowering the serum lipid parameters (P<0.05 or P<0.01). Effect of TLC in treating DN-CRF might be through lowering the levels of blood lipids and serum TGF-beta1.