Vitamin D and bone quality

Active vitamin D analogs such as alfacalcidol have been shown to reduce fracture risk in clinical trials in spite of its moderate effects on bone mass. It has been reported that active vitamin D analogs may improve bone quality, by amelioration of bone microarchitecture, by specific effect on cortic...

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Bibliographic Details
Published inClinical calcium Vol. 15; no. 6; p. 1026
Main Authors Shiraishi, Ayako, Kubota, Naoki, Kubodera, Noboru
Format Journal Article
LanguageJapanese
Published Japan 01.06.2005
Subjects
Animals
Bone and Bones - drug effects
Humans
Vitamin D - pharmacology
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Summary:Active vitamin D analogs such as alfacalcidol have been shown to reduce fracture risk in clinical trials in spite of its moderate effects on bone mass. It has been reported that active vitamin D analogs may improve bone quality, by amelioration of bone microarchitecture, by specific effect on cortical bones, by acceleration of calcification, and by effect on nature of bone matrix proteins. The bone quality assessments that clarify the effect on bone mechanical properties will become important for the positioning of osteoporosis drugs.
ISSN:0917-5857