Expression of the metastasis-associated gene 1 in laryngeal squamous cell carcinoma: correlation with cervical lymph node metastasis

• Published in: Zhonghua er bi yan hou ke za zhi Vol. 38; no. 3; p. 213
• Main Authors: Tang, Qiao-fei, Ji, Wen-yue, Pan, Zi-min, Zheng, Yan, Guan, Chao
• Format: Journal Article
• Language: Chinese
• Published: China 01.06.2003
• Subjects: Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - secondary; Female; Histone Deacetylases - biosynthesis; Histone Deacetylases - genetics; Humans; Laryngeal Neoplasms - metabolism; Laryngeal Neoplasms - pathology; Lymph Nodes - pathology; Lymphatic Metastasis - genetics; Male; Middle Aged; Neck; Repressor Proteins - biosynthesis; Repressor Proteins - genetics; RNA, Messenger - biosynthesis; RNA, Messenger - genetics; Trans-Activators
• ISSN: 0412-3948

The purpose of study was to examine the mRNA expression levels of the metastasis-associated gene1 (MTA1) in laryngeal squamous cell carcinoma (LSCC), so to evaluate its relationship with metastases. Forty-eight surgically resected primary LSCC (16 supraglotti laryngeal carcinomas with cervical lymph node metastasis, 16 supraglotti laryngeal carcinomas with cervical lymph node-negative metastasis, 16 glottic carcinoma with cervical lymph node-negative metastasis) and 16 normal laryngeal mucosa was examined for mRNA expression of MTA1 by reverse transcription-polymerase chain reaction(RT-PCR). The frequency of MTA1 mRNA positive expression in 16 LSCC with cervical lymph node metastasis was 100%, but no expression of MTA1 mRNA was observed in other LSCC with cervical lymph node-negative metastasis (16 supraglotti laryngeal carcinomas and 16 glottic carcinoma) and 16 normal laryngeal mucosa. MTA1 gene is strongly related to cervical lymph node metastasis of LSCC, and may serve as a early diagnosis indicator.