Association study of chromosome 4 STRs polymorphisms with nasopharyngeal carcinoma

• Published in: Yíchuán Vol. 28; no. 7; p. 783
• Main Authors: Guo, Xiu-Chan, O'Brien, Stephen J, Winkler, Cheryl, Scott, Kevin, Hutcheson, Holli, David, Victor, Kessing, Bailey, Zheng, Yu-Ming, Liao, Jian, Lui, Yan, Guy, de The, Zeng, Yi
• Format: Journal Article
• Language: Chinese
• Published: China 01.07.2006
• Subjects: Adolescent; Adult; Aged; Antibodies, Viral - blood; Carcinoma - genetics; Carcinoma - immunology; Carcinoma - virology; Case-Control Studies; China; Chromosomes, Human, Pair 4 - genetics; Cohort Studies; Epstein-Barr Virus Infections - genetics; Epstein-Barr Virus Infections - immunology; Epstein-Barr Virus Infections - virology; Female; Genome-Wide Association Study; Humans; Male; Microsatellite Repeats; Middle Aged; Nasopharyngeal Neoplasms - genetics; Nasopharyngeal Neoplasms - immunology; Nasopharyngeal Neoplasms - virology; Pedigree; Polymorphism, Genetic; Young Adult; China
• ISSN: 0253-9772

Nasopharyngeal carcinoma (NPC) is a complex disease caused by an interaction of EBV chronic infection, environment and host genes, in a multi-step process of carcinogenesis. However, which genetic factors play an important role in the development of chronic EBV infection and NPC remain elusive. The objective of this study is to identify genetic variations associated with two key clinical stages of NPC development: persistent Epstein-Barr virus (EBV) infection of nasopharyngeal epithelia and progression to NPC. We inspected a NPC-associated region on the short arm of chromosome 4 previously implicated by a genome-wide linkage analysis of familial NPC. We determined genotypes for 319 alleles in 34 microsatellite markers spanning an 18 Mb region in 350 NPC cases, 288 individuals with IgA antibodies to EBV capsid antigen (IgA/VCA+) and 346 controls seronegative for IgA antibodies to EBV capsid antigen (IgA/VCA-). The cases and controls were Han Chinese from Wuzhou city and Cangwu County, Guangxi province where th