Preparation of puerarin solid self-microemulsion

To prepare puerarin solid self-microemulsifying drug delivery system (SMEDDS). Pseudo-ternary phase diagram was used to select the formula of microemulsion. The self-microemulsification efficiency was assessed, such as viscosity, conductance, refraction, zeta potential, size ditribution, dissolution...

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Bibliographic Details
Published inZhong yao cai Vol. 29; no. 8; p. 834
Main Authors Yu, Ai-Hua, Zhai, Guang-Xi, Cui, Jing, Liu, Hong
Format Journal Article
LanguageChinese
Published China 01.08.2006
Subjects
Biological Availability
Drug Delivery Systems - methods
Drug Stability
Emulsions
Isoflavones - administration & dosage
Isoflavones - chemistry
Isoflavones - pharmacokinetics
Plant Roots - chemistry
Plants, Medicinal - chemistry
Pueraria - chemistry
Solubility
Surface-Active Agents - chemistry
Water
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Summary:To prepare puerarin solid self-microemulsifying drug delivery system (SMEDDS). Pseudo-ternary phase diagram was used to select the formula of microemulsion. The self-microemulsification efficiency was assessed, such as viscosity, conductance, refraction, zeta potential, size ditribution, dissolution were investigated. Puerarin were determined by UV to calculate the cumulative release at different time. The optimum formulation of puerarin solid self-microemulsifying drug delivery system the consisted of puerarin-Tween 800 glycerinum-ethyl oleate-water-Gum Acacia-manicol at weight ratio of 1.7: 16. 6: 16. 6: 16. 6 : 1.3: 4.0: 39.9: 19.9; Average particle diameter was 30 nm; The dissolution was 94.29% at 10 min. Stability of puerarin solid self-microemulsion drug delvery system is good, potent in improving the dissolution of puerarin.
ISSN:1001-4454