Changes of prostaglandin D2 receptor on T cells in peripheral blood of children with asthma

Chronic airway inflammation is associated with the polarization of TH2 cells in asthma. Prostaglandin D2 (PGD2) plays an important role in the polarization of TH2 cells. This study aimed to investigate the changes of PGD2 receptors (DP1/CRTH2) on T lymphocytes and their significance in asthma. Seven...

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Bibliographic Details
Published inZhongguo dang dai er ke za zhi Vol. 11; no. 3; p. 199
Main Authors Ying, Yan-Feng, Hu, Ye, Shan, Xiao-Yun, Du, Juan, Tu, Ping-Guang
Format Journal Article
LanguageChinese
Published China 01.03.2009
Subjects
Asthma - etiology
Asthma - immunology
Asthma - therapy
Child
Child, Preschool
Chromosome Mapping
Cytokines - blood
Female
Humans
Male
Receptors, Immunologic - blood
Receptors, Prostaglandin - blood
T-Lymphocytes - chemistry
Th2 Cells - immunology
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Summary:Chronic airway inflammation is associated with the polarization of TH2 cells in asthma. Prostaglandin D2 (PGD2) plays an important role in the polarization of TH2 cells. This study aimed to investigate the changes of PGD2 receptors (DP1/CRTH2) on T lymphocytes and their significance in asthma. Seventy-two children with asthma were assigned to two groups: acute attack (n=42) and remission (n=30). Thirty-five healthy children were used as the control group. Plasma levels of TH2 cytokines IL-4 and IL-5, and TH1 cytokine INF-gamma were detected using ELISA. Radiological binding assay (RBA) was used to measure the contents of DP1/CRTH2 receptors on T cells in peripheral blood (PPB). The total combining contents of DP and CRTH2 on T cells in PPB in the acute attack and the remission groups were significantly higher than those in the control group (p<0.01). There was no significant difference in the DP1 content among the three groups. Serum levels of IL-4 and IL-5 significantly increased (p<0.01), in contrast, serum
ISSN:1008-8830