The genotoxic effect of the new acaricide etoxazole

Etoxazole is a member of the diphenyl oxazoline class of insecticide was newly developed for use on pome fruits, cotton and strawberries as a acaricide. In the present study, genotoxic effects of acaricide etoxazole (ETX) (miticide/ovicide) were investigated using chromosome aberration (CA) test, si...

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Bibliographic Details
Published inGenetika Vol. 40; no. 11; p. 1571
Main Authors Rencüzoğullari, Eyyüp, Ila, Hasan Basri, Kayraldiz, Ahmet, Arslan, Mehmet, Diler, Songül Budak, Topaktaş, Mehmet
Format Journal Article
LanguageEnglish
Published Russia (Federation) 01.11.2004
Subjects
Adolescent
Adult
Cells, Cultured
Chromosome Aberrations
Female
Humans
Insecticides - toxicity
Male
Micronucleus Tests
Mutagens - toxicity
Sister Chromatid Exchange
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Summary:Etoxazole is a member of the diphenyl oxazoline class of insecticide was newly developed for use on pome fruits, cotton and strawberries as a acaricide. In the present study, genotoxic effects of acaricide etoxazole (ETX) (miticide/ovicide) were investigated using chromosome aberration (CA) test, sister chromatid exchange (SCE) test and micronucleus test in human lymphocytes. ETX induced the CAs at all concentrations (5, 10 and 20 microg/ml) for 24 h and also induced the CA at the highest concentration (20 microg/ml) for 48 h only. The inducing the CAs for 48 hours treatment period was dose-dependent. Besides, it induced the SCE at all concentrations and treatment periods in a dose-dependent manner as well. Although, ETX decreased the mitotic index (MI) at all concentration and treatment periods dose-dependently, while it did not decrease the replication index (RI) when compared to the negative and solvent controls. In addition, ETX induced the micronucleus at all concentrations except 5 microg/ml for 48 h. This inducing was in a dose-dependent manner as well. In conclusion, it can be concluded that ETX has a potential genotoxic effects in cultured human peripheral lymphocytes.
ISSN:0016-6758