A case of liver metastasis from anorectal malignant melanoma on hemodialysis treated by chemotherapy

• Published in: Gan to kagaku ryoho Vol. 34; no. 10; p. 1709
• Main Authors: Tezuka, Koji, Inaba, Yukio, Hayashi, Ken-ichi, Miura, Takuya, Moriya, Toshiyuki, Takiguchi, Makoto, Isobe, Hideki, Watabe, Shuichi, Yanagawa, Naoki
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.10.2007
• Subjects: Antineoplastic Agents, Alkylating - administration & dosage; Anus Neoplasms - pathology; Anus Neoplasms - surgery; Dacarbazine - administration & dosage; Humans; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - therapy; Liver Neoplasms - drug therapy; Liver Neoplasms - secondary; Male; Melanoma - drug therapy; Melanoma - pathology; Melanoma - secondary; Melanoma - surgery; Middle Aged; Renal Dialysis
• ISSN: 0385-0684

We report a case on hemodialysis with liver metastases from anorectal malignant melanoma treated by dacarbazine (DTIC). A 61-year-old man presented with anal bleeding. An elastic soft mass was palpated in the anal canal, and a biopsy specimen was diagnosed as anorectal malignant melanoma histologically. After introducing hemodialysis for the chronic renal failure, abdominoperineal resection was performed. Two and a half years after surgery, computed tomography showed multiple liver metastases. We chose chemotherapy consisting of DTIC 100 mg for five consecutive days every 4 weeks in addition to hemodialysis (3 times a week). After three cycles of chemotherapy, liver metastases were stable, but new lung metastases were found. After 12 cycles of chemotherapy, liver metastases became stable, but lung metastases were progressive. Subsequently, the patient died of respiratory failure 4 years after surgery, 1 year and 7 months after the diagnosis of multiple liver metastases. No severe toxicity was observed during this period. We conclude that administration of DTIC undergoing hemodialysis for malignant melanoma with renal failure seems to be useful without severe adverse events.