A case of liver metastasis from anorectal malignant melanoma on hemodialysis treated by chemotherapy

We report a case on hemodialysis with liver metastases from anorectal malignant melanoma treated by dacarbazine (DTIC). A 61-year-old man presented with anal bleeding. An elastic soft mass was palpated in the anal canal, and a biopsy specimen was diagnosed as anorectal malignant melanoma histologica...

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Bibliographic Details
Published inGan to kagaku ryoho Vol. 34; no. 10; p. 1709
Main Authors Tezuka, Koji, Inaba, Yukio, Hayashi, Ken-ichi, Miura, Takuya, Moriya, Toshiyuki, Takiguchi, Makoto, Isobe, Hideki, Watabe, Shuichi, Yanagawa, Naoki
Format Journal Article
LanguageJapanese
Published Japan 01.10.2007
Subjects
Antineoplastic Agents, Alkylating - administration & dosage
Anus Neoplasms - pathology
Anus Neoplasms - surgery
Dacarbazine - administration & dosage
Humans
Kidney Failure, Chronic - complications
Kidney Failure, Chronic - therapy
Liver Neoplasms - drug therapy
Liver Neoplasms - secondary
Male
Melanoma - drug therapy
Melanoma - pathology
Melanoma - secondary
Melanoma - surgery
Middle Aged
Renal Dialysis
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Summary:We report a case on hemodialysis with liver metastases from anorectal malignant melanoma treated by dacarbazine (DTIC). A 61-year-old man presented with anal bleeding. An elastic soft mass was palpated in the anal canal, and a biopsy specimen was diagnosed as anorectal malignant melanoma histologically. After introducing hemodialysis for the chronic renal failure, abdominoperineal resection was performed. Two and a half years after surgery, computed tomography showed multiple liver metastases. We chose chemotherapy consisting of DTIC 100 mg for five consecutive days every 4 weeks in addition to hemodialysis (3 times a week). After three cycles of chemotherapy, liver metastases were stable, but new lung metastases were found. After 12 cycles of chemotherapy, liver metastases became stable, but lung metastases were progressive. Subsequently, the patient died of respiratory failure 4 years after surgery, 1 year and 7 months after the diagnosis of multiple liver metastases. No severe toxicity was observed during this period. We conclude that administration of DTIC undergoing hemodialysis for malignant melanoma with renal failure seems to be useful without severe adverse events.
ISSN:0385-0684