Dynamic study on effect of Chinese medicine compound Yiliuyin on angiogenesis in transplanted S180 tumor of mouse

To investigate the dynamic changes in angiogenesis within the tumor tissue of mice bearing S180 tumor at different day-points of oral administration with a Chinese medicine compound "Yiliuyin" (YLY) and to explore the anti-tumor mechanisms of YLY in vivo. Fifty-six BALB/c mice were divided...

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Published inZhongguo zhongyao zazhi Vol. 34; no. 2; p. 212
Main Authors Han, Zhipeng, Wang, Runtian, Li, Tiemin, Yang, Zhiqiang, Cui, Cheng, Ding, Junying, Zhang, Zhengzheng, Deng, Yuqing, Wang, Ping
Format Journal Article
LanguageChinese
Published China 01.01.2009
Subjects
Administration, Oral
Animals
Drugs, Chinese Herbal - administration & dosage
Drugs, Chinese Herbal - pharmacology
Drugs, Chinese Herbal - therapeutic use
Endostatins - metabolism
Female
Gene Expression Regulation, Neoplastic - drug effects
Mice
Mice, Inbred BALB C
Neoplasm Transplantation
Neoplasms - blood supply
Neoplasms - drug therapy
Neoplasms - genetics
Neoplasms - pathology
Neovascularization, Pathologic - drug therapy
Neovascularization, Pathologic - pathology
Vascular Endothelial Growth Factor A - metabolism
Vascular Endothelial Growth Factor Receptor-2 - metabolism
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Summary:To investigate the dynamic changes in angiogenesis within the tumor tissue of mice bearing S180 tumor at different day-points of oral administration with a Chinese medicine compound "Yiliuyin" (YLY) and to explore the anti-tumor mechanisms of YLY in vivo. Fifty-six BALB/c mice were divided into YLY group and control group (28 mice/group) and each group was divided into four subgroups (7 mice/subgroup), randomly. After 24 hrs of inoculation with S180 tumor cells subcutaneously in the right axilla, YLY in the mice of YLY group and equal volume of cold boiled-water in the mice of control group were administered orally twice every day, 0.5 mL each time. The mice of one subgroup from the two groups apiece were killed at 10, 20, 30 th and 40 th day-point of oral administration, respectively. The tumors were isolated and were made into paraffin embedded sections. The dynamic changes of the angiogenesis (CD34 staining), vascular endothelial growth factor (VEGF), vascular endothelial growth factor receptor-2 (VEGFR-2)
ISSN:1001-5302