Intraneural perineurioma: clinical and morphological characteristics and a molecular genetic study of the neurofibromatosis type 2 gene

The authors describe 4 cases of clinically, morphologically, and immunohistochemically typical intraneural perineuriomas that occurred in women aged 17 to 24 years. The tumors involved median, radial, ulnar, and palmar nerves and were 3, 2.5, 1.5, and 1.2 cm in the largest diameter. None patients ha...

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Bibliographic Details
Published inArkhiv patologii Vol. 70; no. 4; p. 20
Main Authors Shelekhova, K V, Sima, R, Orlov, A Iu, Kozakov, D V, Michal, M
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.07.2008
Subjects
Adolescent
Adult
Female
Follow-Up Studies
Humans
Nerve Sheath Neoplasms - genetics
Nerve Sheath Neoplasms - pathology
Neurofibromin 2 - genetics
Peripheral Nerves - pathology
Peripheral Nervous System Neoplasms - genetics
Peripheral Nervous System Neoplasms - pathology
Point Mutation
Retrospective Studies
RNA Splice Sites
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Summary:The authors describe 4 cases of clinically, morphologically, and immunohistochemically typical intraneural perineuriomas that occurred in women aged 17 to 24 years. The tumors involved median, radial, ulnar, and palmar nerves and were 3, 2.5, 1.5, and 1.2 cm in the largest diameter. None patients had signs ofneurofibromatosis type 2 (NF2). One case was studied for mutation of the NF2 gene and heterozygous splice-site mutation at the acceptor splice site between exons 12 and 13 (agGG --> aaGG) was revealed. Two patients were followed up: they were disease-free for 10 and 15 years.
ISSN:0004-1955