Expression and prognostic value of Polo-like kinase 1, E-cadherin in the patients with hepatocellular carcinoma

• Published in: Chung-hua wai kʿo tsa chih Vol. 45; no. 19; p. 1354
• Main Authors: Chen, Xu-jian, Wu, Li-min, Xu, Xiao-bo, Feng, Xiao-wen, Xie, Hai-yang, Zhang, Min, Shen, Yan, Wang, Wei-lin, Liang, Ting-bo, Zheng, Shu-sen
• Format: Journal Article
• Language: Chinese
• Published: China 01.10.2007
• Subjects: Cadherins - genetics; Cadherins - metabolism; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Female; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Liver Neoplasms - genetics; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; Male; Middle Aged; Neoplasm Recurrence, Local; Polo-Like Kinase 1; Prognosis; Protein Serine-Threonine Kinases - genetics; Protein Serine-Threonine Kinases - metabolism; Proto-Oncogene Proteins - genetics; Proto-Oncogene Proteins - metabolism; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; RNA, Messenger - metabolism
• ISSN: 0529-5815

To study the expression of Polo-like kinase 1 (PLK1) and E-cadherin in the tissues of hepatocellular carcinoma, and to discuss the relationship between them and clinical-pathological features, and to evaluate their prognostic value of hepatocellular carcinoma after liver transplantation. mRNA and protein expression of PLK1, E-cadherin were detected by RT-PCR and immunohistochemistry method respectively, the correlations of them with clinical-pathological data, tumor free time, recurrence rate were compared and analyzed. The mRNA expression was observed in 90.0% for PLK1 and 96.0% for E-cadherin, and higher in cancerous' tissues than paracancerous' of all cases for PLK1 but no trend for E-cadherin. The positive and decreased expression rate for PLK1 and E-cadherin was observed in 60.0% and 50.0% respectively, the positive PLK1 expression was correlated with preoperative serum alpha-fetoprotein (AFP) only (chi2 = 4.433, P = 0.035), while E-cadherin expression was associated with none of the clinical-pathologica